Acute and repeated restraint differentially activate orexigenic pathways in the rat hypothalamus
نویسندگان
چکیده
منابع مشابه
Repeated restraint stress enhances glutamatergic transmission in the paraventricular nucleus of the rat hypothalamus.
Corticotropin-releasing hormone (CRH)-synthesizing parvocellular neuroendocrine neurons of the hypothalamic paraventricular nucleus (PVN) play a key role in the activation of the hypothalamic-pituitary-adrenal axis (HPA). It is well known that excitatory and inhibitory inputs that regulate the activity of these neurons may undergo stress-related modifications; however, the effect of repeated re...
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We studied the long term effects of a single exposure to immobilization stress (IS) (1 h) on the expression of anorexigenic (Pro-opiomelanocortin: POMC and cocaine amphetamine related transcript: CART) and orexigenic (neuropeptide Y:NPY, Agouti related peptide: AgRP) factors in hypothalamus and dorso vagal complex (DVC). We showed, by using RT-PCR that in the hypothalamus, that the mRNAs of POM...
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Stress can precipitate onset of multiple mood-related disorders, including depression. Examination of the neural basis of this phenomenon has highlighted the amygdala as a key component. Alterations in amygdalar activity and structure accompany various mood-related disorders, and interestingly, amygdalar morphology and behavior can be altered in animals subjected to repeated stress. Gamma-amino...
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ژورنال
عنوان ژورنال: Regulatory Peptides
سال: 2011
ISSN: 0167-0115
DOI: 10.1016/j.regpep.2010.11.006